Systems and methods for low power pulse oximetry

ABSTRACT

Methods and systems are provided for a light-emitting diode (LED) drive circuit of an optical probe. As an example, a method for an optical probe including an LED in an LED drive circuit comprises reducing power consumption of the LED drive circuit by adjusting a drive voltage of the LED drive circuit based on one or more LED drive circuit characteristics and one or more LED drive circuit operating parameters. In this way, the LED drive circuit may be efficiently operated.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation of U.S. patent application Ser. No.16/180,847, filed on Nov. 5, 2018, entitled “SYSTEMS AND METHODS FOR LOWPOWER PULSE OXIMETERY.” The entire contents of the above-referencedapplication is hereby incorporated by reference for all purposes.

FIELD

Embodiments of the subject matter disclosed herein relate to biologicalprobes, sensors, and methods, and in particular, to photoplethysmographyprobes and methods.

BACKGROUND

Photoplethysmography (PPG) relates to the use of optical signalstransmitted through or reflected by blood-perfused tissues formonitoring a physiological parameter of a subject (also referred to as apatient herein). In this technique, one or more emitters are used todirect light at a tissue, and one or more detectors are used to detectthe light that is transmitted through or reflected by the tissue. Thevolume of blood of the tissue affects the amount of light that istransmitted or reflected, which is output as a PPG signal. As the bloodvolume in a tissue changes with each heartbeat, the PPG signal alsovaries with each heartbeat.

Pulse oximetry is, at present, the standard of care for continuouslymonitoring arterial oxygen saturation (SpO₂). Pulse oximeters includePPG probes that use red (˜660 nm) and infrared (˜940 nm) light todetermine physiological parameters (e.g., blood characteristics) of thesubject, including SpO₂, pulse rate, and pulsating blood flow (e.g.,blood perfusion) at the site of measurement. Conventional pulse oximetryprobes are typically mounted to an extremity of the subject (e.g., afinger or ear lobe).

BRIEF DESCRIPTION

In one embodiment, a method for a pulse oximeter probe including a lightemitting diode (LED) includes reducing power consumption of an LED drivecircuit by adjusting drive voltage of the LED drive circuit based on oneor more LED drive circuit characteristics and one or more LED drivecircuit operating parameters.

Thus, the drive voltage of the LED drive circuit may be adjusteddynamically based on voltage losses of the LED drive circuit, which mayinclude voltage losses measured during manufacture of the probe as wellas voltage losses measured or calculated dynamically during use of theprobe (e.g., when the probe is measuring SpO2, pulse rate, and/orperfusion of a patient). Further, the drive voltage may be adjustedbased on LED drive operating parameters when the probe is used tomeasure patient physiological parameters, which may include LED current,pulse length, and current regulator reference voltage. By measuring orestimating the actual voltage losses, which may vary among probes andchange as probe operation changes (e.g., as patient tissue changes), adrive voltage may be output from a voltage regulator of the drivecircuit that better matches the voltage losses and demands of the LEDdrive circuit, thereby lowering overall power consumption of the probe.

It should be understood that the brief description above is provided tointroduce in simplified form a selection of concepts that are furtherdescribed in the detailed description. It is not meant to identify keyor essential features of the claimed subject matter, the scope of whichis defined uniquely by the claims that follow the detailed description.Furthermore, the claimed subject matter is not limited toimplementations that solve any disadvantages noted above or in any partof this disclosure.

BRIEF DESCRIPTION OF THE DRAWINGS

The present invention will be better understood from reading thefollowing description of non-limiting embodiments, with reference to theattached drawings, wherein below:

FIG. 1 is a block diagram illustrating an example pulse oximetry system.

FIG. 2 schematically shows an example LED drive circuit for a pulseoximetry system.

FIGS. 3A and 3B are a flow chart illustrating an example method forreducing LED drive voltage.

FIG. 4 is a timing diagram illustrating example drive parameters for apulse oximetry system.

DETAILED DESCRIPTION

The following description relates to various embodiments of an opticalprobe. The probe may be included in a pulse oximetry sensor or system,such as the system of FIG. 1 , for determining physiological parametersof a patient. The optical probe may include two light emitters, hereinlight emitting diodes (LEDs), driven by a drive circuit, such as thedrive circuit illustrated in FIG. 2 . Characteristics of the LED drivecircuit affecting the voltage losses may be determined at the time ofmanufacture and during use of the optical probe. LED drive circuitvoltage losses, and thus desired LED voltage, may be estimated based onLED drive circuit characteristics and operating parameters in order todynamically optimize LED drive voltage, as shown by the method of FIGS.3A and 3B. By dynamically optimizing LED drive voltage, the LED drivevoltage may be lowered, thereby lowering power consumption of the pulseoximetry system. Further, a low loss switching voltage regulator may beused to provide the LED drive voltage. To reduce interference, theswitching voltage regulator may be turned off during LED pulses, asshown by the timing diagram of FIG. 4 .

A pulse oximeter comprises a computerized measuring unit and a probeattached to a patient, typically a finger or ear lobe of the patient.The probe includes a light source for sending an optical signal throughtissue of the patient and a photo detector for receiving the signaltransmitted through or reflected from the tissue. On the basis of thetransmitted and received signals, light absorption by the tissue may bedetermined. During each cardiac cycle, light absorption by the tissuevaries cyclically. During the diastolic phase, absorption is caused byvenous blood, non-pulsating arterial blood, cells and fluids in tissue,bone, and pigments. The level of light transmitted at end of thediastolic phase is typically referred to as the “DC component” of thetotal light transmission. During the systolic phase, there is anincrease in light absorption (e.g., a decrease in transmitted light)compared with the diastolic phase due to the inflow of arterial bloodinto the tissue on which the pulse oximetry probe is attached. A crucialpulse oximetry principle is how the measurement can be focused on theblood volume representing the arterial blood only. In pulse oximetry,this is done by taking the pulsating arterial blood portion (the “ACsignal”) from the total transmission signal and normalizing this signalby the “DC” component. The resulting “AC/DC” signal is called the PPGwaveform. Pulse oximetry is thus based on the assumption that thepulsatile component of the absorbance is due to arterial blood only.

In pulse oximetry, arterial blood is typically modeled as containing twospecies of hemoglobin: oxyhemoglobin (HbO₂) and reduced hemoglobin (Hb).Oxyhemoglobin is hemoglobin that is fully saturated with oxygen, andreduced hemoglobin is without oxygen. Arterial oxygen saturationmeasured by pulse oximetry (SpO₂) is defined as the percentage of HbO₂divided by the total amount of hemoglobin (HbO₂+Hb). In order todistinguish between the two species of hemoglobin, light absorption ismeasured at two different wavelengths. The probe of a traditional pulseoximeter includes two different light sources, such as light-emittingdiodes (LEDs) or lasers, that emit light at two different wavelengths.The wavelength values widely used are 660 nm (red light) and 900 nm(infrared light), as the two species of hemoglobin have substantiallydifferent absorption at these wavelengths. Each light source isilluminated in turn at a frequency that is typically several hundred Hz.

Pulse oximeter probes may be used in a variety of medical contexts,including continuous patient monitoring. During continuous patientmonitoring, output from a pulse oximeter probe may be collected and/ordisplayed at a specified rate over a relatively long duration. Theduration of the continuous patient monitoring may vary, but in somecontexts the monitoring may occur for multiple hours or longer. Thus, itmay be desirable to configure the pulse oximeter as a remote sensor thatcommunicates wirelessly with a central unit, thereby allowing a patientundergoing monitoring to be untethered from wired connections andassociated bulky componentry. However, pulse oximeter probes may demanda relatively high amount of power in order to drive the LEDs at theabove-described wavelengths and frequencies, thus limiting the abilityto configure the probes as remote sensors. For example, batteries thatare small and/or inexpensive enough for use in a remote pulse oximetersensor may not store sufficient charge to power the pulse oximeter foran extended amount of time. Further, even in wired systems where amplecharge may be available, power consumption in the pulse oximeter may behigher than necessary, leading to wasted energy use, higher heatdissipation, or other issues.

Pulse oximeter probe LED drive power consumption has a key role in a lowpower pulse oximetry power budget. LED average power consumption isproportional to LED average current and LED drive voltage. Inconventional pulse oximetry, a constant predetermined LED drive voltageis used based on a worst case scenario of the estimated voltage losses(also referred to as a voltage drop) in the LED drive circuit. Thus, inmany cases, the LED drive voltage is higher than necessary, leading tohigher than needed power consumption.

For example, the LED drive voltage is configured to be higher than thevoltage losses in the LED drive circuit. Voltage loss in the LED drivecircuit may be attributed to a voltage drop in a voltage regulator and abulk capacitor, probe cable and connector resistances, a voltage dropover the LEDs, a voltage drop over the current regulator, and a possibleH-bridge voltage drop. In conventional pulse oximetry, the worst casescenario for each of the voltage losses in the LED drive circuit isestimated, and the LED drive voltage is hard coded based on thatanalysis.

Thus, according to embodiments of the disclosure presented herein, LEDdrive voltage may be optimized based on probe manufacturing data writtenin permanent memory and/or based on dynamically determined operatingparameters and measured variables. By optimizing the drive voltage in adynamic manner, power consumption by the pulse oximeter may be reduced,thereby extending battery life and enabling the configuration of thepulse oximeter as a remote sensor.

In an example, the drive voltage may be optimized based on the voltagedrop in the voltage regulator and in the bulk capacitor. Conventionalpulse oximeters use a low efficiency linear regulator to create lownoise LED drive voltage, which may consume excess power. Thus, a lowloss LED drive may be included in the pulse oximeter of the presentdisclosure that is based on a switching voltage regulator. To reduceinterference, the switching regulator may be turned off during an LEDpulse, and the bulk capacitor may be used to provide the energy duringthe LED pulse. The output voltage of the switching regulator may beadjusted with high efficiency to optimize the transmission voltage.

In an example, the drive voltage may be optimized based on the voltagedrop in the bulk capacitor. The voltage drop in the bulk capacitor maybe calculated based on the LED pulse length, LED current, andcapacitance. Thus, the LED pulse length, LED current, and capacitancemay be used to dynamically optimize the LED drive voltage.

In an example, the drive voltage may be optimized based on the probecable and connector resistances and used (e.g., supplied) LED current(LED current may be adjustable, e.g., in range of 10-200 mA). Probecable and connector resistances may be measured during manufacture ofthe pulse oximeter and written to permanent memory to optimize LED drivevoltage. A pulse oximeter monitor may also measure the cable/connectorresistance when the probe is connected and optimize LED drive voltagedynamically.

In an example, the drive voltage may be optimized based on the voltagedrop over the LED. The voltage drop over the LED depends on LED emissionwavelength, materials, and used forward current. The voltage drop overthe LED with different LED currents may be characterized in probemanufacturing. The pulse oximeter may also measure LED anode and cathodevoltages to calculate the voltage drop in the LEDs/probe/LED drive. LEDdrive voltages may be dynamically optimized independently for eachindividual LED of the pulse oximeter based on the estimated voltagelosses.

In an example, the drive voltage may be optimized based on the voltagemeasured over the LED current regulator. The current regulator mayprovide accurate and noise free LED current only if the voltage over thecurrent regulator is kept over a minimum voltage specified for thedriver, e.g., 0.8 V. If the voltage over the current regulator is higherthan the minimum voltage, the extra voltage is converted to heat in theregulator. The voltage may be measured periodically, e.g., once asecond, or when LED peak current or duty cycle (LED pulse length orpulse frequency) is changed and LED drive voltages are adjustedaccordingly. Voltage drop over the LED depends on LED wavelength, andthus it is favorable to have separate LED drive voltage and LED drivercircuits for red and infrared LEDs.

In an example, the drive voltage may be optimized based on an LEDcurrent regulator reference voltage and a possible H-bridge.Conventional pulse oximeters use a constant current regulator referencevoltage that is based on the worst case analysis of, e.g., a desiredsignal-to-noise ratio (SNR) and a maximum required LED current. Currentregulator voltage loss is dependent on the current regulator referencevoltage. The current regulator reference voltage may be adjusteddynamically based on a LED drive target SNR and a required LED currentdynamic range. A higher reference voltage provides higher SNR and higherLED drive current. The LED drive target SNR may be set based on aperfusion of tissue being measured by the pulse oximeter probe. Forexample, when the perfusion (e.g., % modulation) is higher than athreshold, the target SNR may be reduced. The threshold may correspondto a perfusion value above which higher SNRs will not result in moreaccurate perfusion measurements. The maximum required LED current can bedetermined based on, e.g., the system SNR target and tissue attenuation.When the LED drive target SNR or current driver maximum LED current isdecreased, the current regulator reference voltage and the LED drivevoltage can be decreased accordingly. The LED drive voltage also can beoptimized dynamically based on the LED scheme (common cathode vs. backto back); the common cathode LED scheme does not require an H-bridge,and thus, the required LED drive voltage is lower.

FIG. 1 is a block diagram of one embodiment of a multi-wavelength pulseoximetry system 10. Light transmitted from an emitter unit 100 passesinto patient tissue 102. The emitter unit includes multiple lightsources 101, such as light-emitting diodes (LEDs), with each lightsource having a dedicated wavelength. Each wavelength forms onemeasurement channel on which PPG waveform data are acquired. The numberof sources/wavelengths is at least two.

The light transmitted through the tissue 102 is received by a detectorunit 103, which comprises two photo detectors 104 and 105 in thisexample. For example, photo detector 104 may be a silicon photodiode,and photo detector 105 may be a second silicon photodiode with differentspectral characteristics or an indium gallium arsenide (InGaAs)photodiode. The emitter and detector units form a probe subunit 13 ofthe pulse oximetry system 10. In some examples, the photo detectors maybe configured/arranged to receive light which has reflected from thetissue in addition to or alternatively to receiving light that istransmitted through the tissue.

The probe subunit 13 may be coupled to a drive and processing subunit 11via a cable 107 and one or more connectors. For example, a connector maybe present on an end of cable 107 to connect cable 107 and probe subunit13 to drive and processing subunit 11. In this way, probe subunit 13 maybe removably coupled to drive and processing subunit 11. In otherexamples, probe subunit 13 and drive and processing subunit 11 may beintegrated into the same housing.

Drive and processing subunit 11 may include an input amplifier unit 106and an emitter drive unit 108. The photo detectors convert the opticalsignals received into electrical pulse trains and feed them to an inputamplifier unit 106. The amplified measurement channel signals arefurther supplied to a control unit 110, which executes instructionsstored in memory 112 to convert the signals into digitized format foreach wavelength.

The control unit 110 further controls emitter drive unit 108 toalternately activate the light sources. To activate the light sources,the emitter drive unit 108 may include a voltage source, such as abattery, which will be described in more detail below. As mentionedabove, each light source is typically illuminated several hundred timesper second. With each light source being illuminated at such a high ratecompared to the pulse rate of the patient, the control unit 110 obtainsa high number of samples at each wavelength for each cardiac cycle ofthe patient. The value of these samples varies according to the cardiaccycle of the patient, the variation being caused by the arterial blood.

The digitized PPG signal data at each wavelength may be stored in memory112 of the control unit 110 before being processed further according tonon-transitory instructions (e.g., algorithms) executable by the controlunit 110 to obtain physiological parameters. Memory 112 may comprise asuitable data storage medium, for example, a permanent storage medium,removable storage medium, and the like. Additionally, memory 112 may bea non-transitory storage medium. In some examples, the system 10 mayinclude a communication subsystem 117 operatively coupled to one or moreremote computing devices, such as hospital workstations, smartphones,and the like. The communication subsystem 117 may enable the output fromthe detector units (e.g., the digitized PPG signal data) to be sent tothe one or more remote computing devices for further processing and/orthe communication subsystem may enable the output from the algorithmsdiscussed below (e.g., determined physiological parameters) to be sentto the remote computing devices. The communication subsystem 117 mayinclude wired and/or wireless communication devices compatible with oneor more different communication protocols. As non-limiting examples, thecommunication subsystem 117 may be configured for communication via awireless telephone network, a local- or wide-area network, and/or theInternet.

Algorithms may utilize the same digitized signal data and/or resultsderived from the algorithms and stored in the memory 112, for example.For example, for the determination of oxygen saturation and pulsetransit time (PTT), the control unit 110 is adapted to execute an SpO₂algorithm and a PTT algorithm, respectively, which may also be stored inthe memory 112 of the control unit 110. Additional algorithms, such as ablood pressure algorithm, a hypovolemia algorithm, and a respirationrate algorithm, may also be stored in memory 112 for determining bloodpressure, an indication of hypovolemia, and respiration rate,respectively. The obtained physiological parameters and waveforms may beshown on a screen of a display unit 114. Further, in some examples, thecontrol unit, memory, and/or other subsystems may be located remotelyfrom the rest of the sensor on a separate device, and the signal datafrom the detector units may be sent to the separate device forprocessing.

The input amplifier unit 106, the control unit 110 and memory 112, theemitter drive unit 108, probe subunit 13, and/or additional components(the display unit, for example) may collectively form a sensor. As usedherein, the term “probe” may refer to the probe and the attachment partsthat attach the optical components of the probe to the tissue site. Theterm pulse oximeter or sensor may refer to a unit comprising a probe, ananalog front end, and a signal processing unit that calculates SpO₂ andother blood characteristics. In a multi-parameter body area networksystem, the system typically represents a set of multiple sensors, e.g.,the different physiological parameter measurements. Therefore, the wholemeasurement system may comprise of several sensors and their associatedprobes, and the sensors may communicate to a common hub in which theparameters' information is integrated.

As used herein, the terms “sensor,” “system,” “unit,” or “module” mayinclude a hardware and/or software system that operates to perform oneor more functions. For example, a sensor, module, unit, or system mayinclude a computer processor, controller, or other logic-based devicethat performs operations based on instructions stored on a tangible andnon-transitory computer readable storage medium, such as a computermemory. Alternatively, a sensor, module, unit, or system may include ahard-wired device that performs operations based on hard-wired logic ofthe device. Various modules or units shown in the attached figures mayrepresent the hardware that operates based on software or hardwiredinstructions, the software that directs hardware to perform theoperations, or a combination thereof.

“Systems,” “units,” “sensors,” or “modules” may include or representhardware and associated instructions (e.g., software stored on atangible and non-transitory computer readable storage medium, such as acomputer hard drive, ROM, RAM, or the like) that perform one or moreoperations described herein. The hardware may include electroniccircuits that include and/or are connected to one or more logic-baseddevices, such as microprocessors, processors, controllers, or the like.These devices may be off-the-shelf devices that are appropriatelyprogrammed or instructed to perform operations described herein from theinstructions described above. Additionally or alternatively, one or moreof these devices may be hard-wired with logic circuits to perform theseoperations.

FIG. 2 schematically shows an example of LED drive and detector circuits200, which may be included as part of pulse oximetry system 10 of FIG. 1. LED drive and detector circuits 200 includes two light emitters,herein in the form of a first light emitting diode (LED) 202 and secondLED 204. When supplied with current at or above a threshold level, firstLED 202 emits light of a given wavelength range, such as a range between620 and 690 nm for red light. Second LED emits light in different range,such as in a range between 860 nm and 950 nm for infrared light. Battery206 may be selectively couplable to the drive circuit to provide a drivevoltage for illuminating the LEDs. As shown, battery 206 is coupled to avoltage regulator. The voltage regulator may be a two-channel switchingregulator. For example, the voltage regulator includes a first channel(voltage regulator CH1 208) and a second channel (voltage regulator CH2210). Voltage regulator CH1 208 and voltage regulator CH2 210 may becontrolled according to signals received from timing unit 222 (includedas part of an analog front end (AFE) 230).

The circuit between voltage regulator CH1 and first LED 202 includes afirst bulk capacitor 212. Likewise, the circuit between voltageregulator CH2 and second LED 204 includes a second bulk capacitor 214.Each of the bulk capacitors may be charged when the respective voltageregulator channel is turned on. When a respective LED is commanded on(e.g., commanded to illuminate), current may be supplied to the LED fromthe bulk capacitor and the respective voltage regulator channel may beturned off. In some examples, the switching voltage regulator may be abuck-boost type regulator, and regulator switching may be turned offduring a LED pulse to reduce interference coupling from the switchingregulator to the LED current.

Pulse control of the LEDs may be provided by an LED control unit 216,which may be part of the AFE 230. LED control unit 216 may include avoltage controller 218 and a current regulator 220. For example, voltagecontroller 218 may include an input to receive pulse width modulation(PWM) data representative of what times during a corresponding PWM cycle(or other duration) LED 202 and LED 204 are to be activated. Voltagecontroller 218 may further include additional inputs to receive LEDcurrent (e.g., from current regulator 220) and a voltage headroommeasurement. The LED control 216 may be configured to control theswitching and voltage level of the voltage regulators.

Voltage controller 218 may additionally receive manufacturing dataindicative of certain parameters of the drive circuit/pulse oximeterdetermined during manufacture (such as the forward voltage of each LED,any cable or connector resistances, etc.). The voltage headroommeasurement may include the voltage over the current regulator. Voltagecontroller 218 may adjust the output voltage based on the manufacturingdata, voltage headroom, LED current, and/or other factors, as describedin more detail below.

Timing unit 222 may output a stop signal to turn off the switchingvoltage regulator of CH1 208 and CH2 210 during LED pulses (e.g., whenLED 202 or LED 204 is illuminated). Timing unit 222 may also send asignal to current regulator 220 to activate/deactivate LED 202 or LED204. Current regulator 220 is configured to maintain the current I1flowing through LED 202 at or near a desired current (e.g., 100 mA) whenactive and maintain the current I2 flowing through LED 204 at or near adesired current (e.g., 100 mA) when active. The current flowing througheach LED may be adjusted based on tissue attenuation or otherparameters, and may be in a range of 10-200 mA.

AFE 230 may include further components, including an analog to digitalconverter 224, high-frequency and/or low-frequency oscillators, andinput/output ports to communicate with the voltage regulator and with amemory (e.g., memory 112). AFE 230 further includes a detector circuitthat includes a receive channel 226 and a photo detector 228. Photodetector 228 is anon-limiting example of photo detector 104 and/or 105.Photo detector 228 may detect light that is emitted from LED 202 and/or204 (and that passes through intervening tissue) and send signalsindicative of the received light to receive channel 226.

Turning now to FIGS. 3A and 3B, a flow chart illustrating a method 300for reducing power consumption in a pulse oximeter is shown. Method 300and the other methods described herein may be performed with a pulseoximetry system, such as pulse oximetry system 10 shown in FIG. 1 . Morespecifically, method 300 may be executed by a control unit of the pulseoximetry system (such as control unit 110 shown in FIG. 1 ) according toinstructions stored on a non-transitory memory of the system (e.g.,memory 112 shown in FIG. 1 ) in combination with the various signalsreceived at the control unit from the system components and actuationsignals sent from the control unit to the emitter drive unit, inputamplifier unit, etc.

Method 300 begins at 302 and includes determining voltage losses relatedto LED drive circuit characteristics during manufacture and storing thelosses in memory. The LED drive circuit may include various componentsfor illuminating one or more LEDs, such the components of LED drive anddetector circuits 200 described with respect to FIG. 2 . Therefore,separate voltage losses may be determined for individualcomponents/subsets of components and added together to determine a totalvoltage drop. Determining the voltage losses related to thecharacteristics of the LED drive circuit includes determining cablelosses by measuring probe cable and connector resistances, as indicatedat 304. For example, the probe cable (e.g., cable 107 of FIG. 1 ) andconnector resistances may be measured using an ohmmeter. Determining thevoltage losses related to the characteristics of the LED drive circuitincludes measuring a voltage drop (forward voltage) over each LED withone or more different forward currents, as indicated at 306. LED forwardvoltage depends on, e.g., a wavelength of the LED, materials thatcomprise the LED, LED internal and bonding resistances, and used forwardcurrent. LED forward voltage has large unit to unit variance. Forwardvoltage of each individual LED may be measured in probe manufacturingand written to permanent memory. Determining the voltage losses relatedto the LED drive circuit characteristics further includes estimating ordetermining remaining losses. For example, as indicated at 308, bulkcapacitor capacitance (e.g., of capacitor 212 and/or 214) may bemeasured and written to permanent memory. Further, current regulatorvoltage losses and a possible H-bridge voltage drop may be determined.

At 309, method 300 optionally includes receiving an indication that theprobe is attached to tissue and/or ready to start measuring. Theindication may include the probe being powered on and/or an operatorentering an input commanding the probe to commence measurement. Afterthe probe is applied to the measurement site, method 300 includessetting initial LED drive circuit operating parameters at 310. Theinitial LED drive circuit operating parameters may include LED current,LED pulse length, LED pulse frequency, and current driver referencevoltage, as indicated at 312, or other suitable parameters.

At 314, method 300 includes estimating voltage losses in the LED drivecircuit based on the used LED drive circuit operating parameters and LEDdrive circuit characteristics. Because the determined voltage losses arespecific to each LED in a single pulse oximeter probe, the initial drivevoltage may be different for each LED in the probe. As a non-limitingexample, the initial drive voltage may be 3.6 V for the red LED and 3.0V for the IR LED. Furthermore, because determined voltage losses mayvary from probe to probe, the initial drive voltage may also bedifferent from unit to unit. The initial LED drive operating parametersalong with the determined LED drive characteristics may be stored inmemory 112 of the control unit 110. Alternatively, probe relatedcharacteristics also may be stored in a memory located in the probe.

Estimating the voltage losses during probe use may include calculating avoltage loss of the bulk capacitor based on LED pulse length, LEDcurrent, and capacitance, as indicated at 316. The LED pulse length andLED current are known to and controlled by the LED control unit,including a current regulator (e.g., current regulator 220 of FIG. 2 ).The capacitance is a property of the capacitor, which may be determinedduring manufacture and stored in memory. The pulse oximeter control unitmay input the LED pulse length, the LED current, and the capacitanceinto one or more look-up tables, maps, or functions and output thevoltage loss of the bulk capacitor, for example.

Estimating the voltage losses may include estimating a voltage dropacross the LED based on LED forward voltage data measured with differentLED currents in manufacturing and used LED current, as indicated at 318.The voltage drop may be interpolated based on the forward voltage valuesmeasured in manufacturing.

Estimating the voltage losses during probe use may further includedetermining probe cable and connector related voltage loss, as indicatedat 320, for example using resistances measured in manufacturing, or theprobe cable and connector resistances may be monitored while the pulseoximeter probe is connected, such as based on the voltage across thecable and the current through the cable (e.g., according to Ohm's law).Voltage across the current regulator may also be measured to ensure itis higher than the current regulator voltage headroom specificationdetermined in the manufacturing.

Estimating the voltage losses during probe use may further includedetermining current regulator voltage loss, as indicated at 322. Thecurrent regulator voltage loss is dependent on the current regulatorreference voltage. The current regulator reference voltage may beadjusted dynamically based on a required LED drive target SNR and arequired LED current dynamic range. A higher reference voltage providesa higher SNR and a higher LED drive current. The LED drive target SNRmay be set based on a perfusion of tissue being measured by the pulseoximeter probe. For example, when the perfusion (e.g., % modulation) ishigher than a threshold, the target SNR may be reduced. The thresholdmay correspond to a perfusion value above which higher SNRs will notresult in more accurate perfusion measurements. A maximum required LEDcurrent can be determined based on, e.g., the system SNR target andtissue attenuation. When the LED drive target SNR or the current drivermaximum LED current is decreased, the current regulator referencevoltage and the LED drive voltage can be decreased accordingly.

At 324, method 300 includes adjusting the drive voltage based on theestimated voltage losses, such as the voltage losses dynamicallydetermined at 314. To adjust the drive voltage, the output voltage fromthe respective voltage regulator may be adjusted. For example, theswitching frequency of the voltage regulator may be adjusted. As anexample, a switching voltage regulator of each LED (e.g., voltageregulator CH1 208 and voltage regulator CH2 210 of FIG. 2 ) receivingvoltage from a battery (e.g., battery 206 of FIG. 2 ) may be adjusted toreach the target drive voltage. By driving the LED circuit with theadjusted drive voltage, which is greater than the estimated voltagelosses, any unit to unit or patient to patient variations will notaffect LED operability.

At 326, method 300 includes turning off the energy flow from theswitching regulator during LED pulses. Each LED is commanded on to emitlight according to a PWM cycle (e.g., as commanded by an LED controlunit, such as LED control unit 216 of FIG. 2 ). During each LED pulse, astop command signal is simultaneously provided from the timing unit tothe respective voltage regulator channel such that the switchingregulator is turned off. Upon completion of the LED pulse, the voltageregulator may be turned on, such as described above at 324. Therefore,the voltage regulator may be switched between the LED pulses but notduring the LED pulses (e.g., the voltage regulator may be effectivelyoff during the LED pulses).

At 328, method 300 includes analyzing probe output signalcharacteristics, such as a current transfer ratio (CTR) and aplethysmograph signal amplitude. Based on the characteristics of theprobe output signal, the LED drive circuit operating parameters may beadjusted to maintain a high SNR plethysmograph measurement, as indicatedat 330. Adjusting the LED drive circuit operating parameters may includeadjusting the LED current and pulse length based on the measured CTR, asindicated at 332. Additionally or alternatively, adjusting the LED drivecircuit operating parameters may include adjusting the current regulatorreference voltage based on the CTR and the plethysmograph signalamplitude, as indicated at 334.

At 336, method 300 includes determining if any LED drive operatingparameters have changed. For example, as described above, the LEDcurrent and pulse length and/or current regulator reference voltage maybe adjusted based on the CTR. If the LED drive operating parameters havechanged, method 300 proceeds to 338 to determine if the change inoperating parameters includes the probe being switched off and/orremoved from the tissue site. If yes, method 300 ends. If the probe isstill operating, method 300 goes back to 314 to estimate voltage lossesbased on the updated LED drive operating parameters and then againadjusts the drive voltage according to the estimated voltage losses. Ifat 336 no change in operating parameters are detected, for example, ifno adjustments to the LED current and pulse length and/or the currentregulator reference voltage were made, method 300 loops back to 326 tocontinue switching off the energy flow from the switching regulatorduring the LED pulses, analyze the probe output characteristics, andadjust the LED drive circuit operating parameters based on the probeoutput signal characteristics.

In this way, an LED drive voltage may be minimized based on datadetermined during probe manufacture and further based on operatingparameters and measurements obtained during pulse oximeter probe use.The LED drive voltage may be optimized for each LED of the probe suchthat the drive voltage of each LED is minimized. In this way, LED powerconsumption may be reduced, resulting in longer probe battery lifeand/or smaller battery size.

Next, FIG. 4 shows an example timeline 400 of drive parameters of an LEDdrive circuit of a pulse oximeter during operation, such as LED driveand detector circuit 200 of FIG. 2 . Although timeline 400 showsoperation of one LED drive circuit, it should be understood that asecond LED drive circuit may be operated similarly, simultaneously or insequence. Battery current is shown in plot 402, voltage regulatorswitching is shown in plot 404, a switching stop command is shown inplot 406, an output voltage of a bulk capacitor is shown in plot 408,and an LED load current is shown in plot 410. For all of the above, thehorizontal axis represents time, with time increasing along thehorizontal axis from left to right. The vertical axis represents eachlabeled parameter. For plots 402, 408, and 410, the value of the labeledparameter increases along the vertical axis from bottom to top. For plot404, each arrow represents a switching event. The frequency of theswitching event is high when capacitor voltage is charged (408) to thetarget value (412) and low when capacitor voltage is maintained at thetarget value. For plot 406, the vertical axis represents whether theswitching stop command is “on” or “off,” as labeled.

Prior to time t1, the LED (e.g., first LED 202 of FIG. 2 ) is off, andthus, the LED load current is zero (plot 410) and the switching stopcommand is off (plot 406). For example, the LED may be operated at a 5%duty cycle, and thus, the LED load current may be equal to zero for amajority of an on-and-off cycle. While the LED is off, the voltageregulator (e.g., voltage regulator CH1 208 of FIG. 2 ) undergoesperiodic switching (plot 404) in order to maintain the output voltage ofthe bulk capacitor (e.g., first bulk capacitor 212 of FIG. 2 ) at afirst target voltage indicated by dashed line 412. The first targetvoltage serves as a first drive voltage of the LED drive circuit. Asdescribed with respect to method 300 of FIGS. 3A and 3B and the systemof FIG. 2 , the switching frequency of the voltage regulator may becontrolled by a timing unit (e.g., timing unit 222 of FIG. 2 ). With thevoltage regulator turned on to provide current to the bulk capacitor,the battery current (e.g., a current of battery 206 of FIG. 2 ) is at anon-zero value. Note that the battery may supply current to additionalpulse oximeter components in addition to the LED drive circuit of FIG. 4.

Between time t1 and time t2, the LED is switched on, with the LED loadcurrent increasing for a load pulse (plot 410). As an example, the loadpulse may be 100 mA, and the pulse duration (e.g., a duration betweentime t1 and time t2) may be 150 μs. A timing of the load pulse iscontrolled by the timing unit. Simultaneously to the load pulse,beginning at time t1 and ending at time t2, the timing unit turns on theswitching stop command (plot 406) such that the voltage regulator doesnot undergo switching (plot 404) between time t1 and time t2. While thevoltage regulator is off and does not supply current to the bulkcapacitor, the battery current decreases (plot 402). Furthermore, theoutput voltage of the bulk capacitor decreases (plot 408) as the bulkcapacitor supplies current to the LED during the commanded load pulse.

Upon completion of the load pulse at time t2, the LED load currentreturns to zero (plot 410) and the switching stop command is turned off(plot 406). With the switching stop command turned off, the voltageregulator undergoes switching (plot 404) to charge the bulk capacitor.The frequency of switching during the charging is greater than prior totime t1, when the switching was used to maintain the output voltage atthe first target voltage (dashed line 412), and the output voltage ofthe bulk capacitor (plot 408) increases as it is charged. Due to themore frequent switching between time t2 and time t3, the battery currentincreases (plot 402). Furthermore, based on determined voltage losseswhile operating the LED, a controller of the pulse oximeter maydetermine an updated, second target output voltage (dashed line 414),serving as an updated drive voltage of the LED drive circuit. Once theoutput voltage of the bulk capacitor (plot 408) reaches the secondtarget output voltage (dashed line 414), the frequency of the voltageregulator switching (plot 404) decreases in order to maintain thevoltage output of the bulk capacitor at the second target outputvoltage.

In this way, by optimizing the drive voltage in a dynamic manner, pulseoximeter LED drive power consumption may be reduced, thereby extendingbattery life and enabling the configuration of the pulse oximeter as aremote sensor. The configuration of the pulse oximeter as a remote probeenables continuous patient monitoring with fewer restrictions on patientmovement and location. Furthermore, by extending pulse oximeter probebattery life, demands on healthcare staff may be reduced.

The technical effect of dynamically optimizing a drive voltage of an LEDcircuit based on measured voltage losses is that LED circuit powerconsumption is minimized.

An example provides a method for an optical probe including a lightemitting diode (LED) in an LED drive circuit, the method includingreducing power consumption of the LED drive circuit by adjusting drivevoltage of the LED drive circuit based on one or more LED drive circuitcharacteristics and one or more LED drive circuit operating parameters.In a first example of the method, adjusting a drive voltage of the LEDdrive circuit comprises adjusting a voltage regulator of the LED drivecircuit to supply an adjusted output voltage. In a second example of themethod, which optionally includes the first example, the voltageregulator is a switching voltage regulator, and the method furtherincludes turning off or de-coupling the switching voltage regulatorduring each transmission pulse of the LED. In a third example of themethod, which optionally includes one or both of the first and secondexamples, one or more of the one or more LED drive circuitcharacteristics are determined during manufacture of the probe. In afourth example of the method, which optionally includes one or more oreach of the first through third examples, the one or more LED drivecircuit characteristics determined during manufacture of the probecomprise one or more of measured probe cable resistance, measured probeconnector resistance, and a voltage drop across the LED with differentforward currents. In a fifth example of the method, which optionallyincludes one or more or each of the first through fourth examples, theone or more LED drive characteristics comprise a voltage drop across theLED with different forward currents, and the one or more LED drivecircuit operating parameters comprise used LED current. In a sixthexample of the method, which optionally includes one or more or each ofthe first through fifth examples, the one or more LED drive circuitcharacteristics comprise a capacitance of a bulk capacitor of the LEDdrive circuit, and the one or more LED drive circuit operatingparameters comprise LED pulse length and LED current.

Another example provides a method for an optical probe including a lightemitting diode (LED) driven by a drive circuit including a voltageregulator and a LED current regulator, the method including setting anLED current regulator reference voltage to an initial value; with theLED current regulator reference voltage at the initial value, measuringprobe output signal characteristics; adjusting the LED current regulatorreference voltage based on the probe output signal characteristics; andadjusting the LED drive voltage according to the LED current regulatorreference voltage. In a first example of the method, the probe outputsignal characteristics comprise one or more of a plethysmograph signalamplitude and signal attenuation. In a second example of the method,which optionally includes the first example, the method further includesadjusting the LED drive voltage based on one or more LED drive circuitcharacteristics determined during manufacture of the probe. In a thirdexample of the method, which optionally includes one or both of thefirst and second examples, the one or more LED drive circuitcharacteristics determined during manufacture of the probe comprise oneor more of a measured probe cable resistance, a measured probe connectorresistance, and a voltage drop across the LED with different forwardcurrents. In a fourth example of the method, which optionally includesone or more or each of the first through third examples, the methodfurther includes adjusting the LED drive voltage based on one or more ofLED current and pulse length. In a fifth example of the method, whichoptionally includes one or more or each of the first through fourthexamples, setting the LED current regulator reference voltage to theinitial value comprises setting the LED current regulator referencevoltage to an initial value determined during manufacture of the probe.

Another example provides for a system for an optical probe, including alight emitter; a light detector configured to measure transmissionand/or reflectance of light emitted by the light emitter through bloodof a patient and output a light signal to a control unit; and a drivecircuit configured to control the light emitter, the drive circuitcomprising: a switching voltage regulator; a bulk capacitor coupled tothe switching voltage regulator and to the light emitter; and a controlunit configured turn off or decouple the switching voltage regulatorduring each light transmission pulse of the light emitter and turn onthe switching voltage regulator during inter-pulse periods to charge thebulk capacitor. In a first example of the system, the control unitprocesses the light signal to calculate one or more physiologicalparameters of the patient. In a second example of the system, whichoptionally includes the first example, the control unit is configured toadjust an output voltage of the switching voltage regulator based on oneor more voltage losses of the LED drive circuit. In a third example ofthe system, which optionally includes one or both of the first andsecond examples, the one or more voltage losses of the LED drive circuitcomprise one or more of a voltage drop across the bulk capacitor, avoltage drop across the light emitter, a cable resistance, a connectorresistance, and an LED drive current regulator voltage loss. In a fourthexample of the system, which optionally includes one or more or each ofthe first through third examples, the control unit is configured todynamically update one or more of the voltage drop across the bulkcapacitor, the cable resistance, the connector resistance, and the LEDdrive current regulator voltage loss when the light emitter is activatedand the light detector is measuring the transmission and/or reflectanceof the light emitted by the light emitter.

As used herein, an element or step recited in the singular and proceededwith the word “a” or “an” should be understood as not excluding pluralof said elements or steps, unless such exclusion is explicitly stated.Furthermore, references to “one embodiment” of the present invention arenot intended to be interpreted as excluding the existence of additionalembodiments that also incorporate the recited features. Moreover, unlessexplicitly stated to the contrary, embodiments “comprising,”“including,” or “having” an element or a plurality of elements having aparticular property may include additional such elements not having thatproperty. The terms “including” and “in which” are used as theplain-language equivalents of the respective terms “comprising” and“wherein.” Moreover, the terms “first,” “second,” and “third,” etc., areused merely as labels and are not intended to impose numericalrequirements or a particular positional order on their objects.

This written description uses examples to disclose the invention,including the best mode, and also to enable a person of ordinary skillin the relevant art to practice the invention, including making andusing any devices or systems and performing any incorporated methods.The patentable scope of the invention is defined by the claims and mayinclude other examples that occur to those of ordinary skill in the art.Such other examples are intended to be within the scope of the claims ifthey have structural elements that do not differ from the literallanguage of the claims or if they include equivalent structural elementswith insubstantial differences from the literal languages of the claims.

The invention claimed is:
 1. A method for an optical probe including alight emitting diode (LED) driven by a drive circuit including an LEDdrive voltage regulator and an LED current regulator, the methodcomprising: with an LED drive voltage and at least one LED drive circuitoperating parameter at initial values, measuring probe output signalcharacteristics; adjusting the at least one LED drive circuit operatingparameter based on the probe output signal characteristics; estimatingLED drive circuit voltage losses based on the at least one LED drivecircuit operating parameter; and adjusting the LED drive voltageaccording to the LED drive circuit voltage losses.
 2. The method ofclaim 1, wherein the at least one LED drive circuit operating parameteris one or more of an LED current, an LED pulse length, an LED pulsefrequency, and a current regulator reference voltage.
 3. The method ofclaim 2, further comprising further adjusting the at least one LED drivecircuit operating parameter in response to a change in one or more ofthe drive circuit operating parameters.
 4. The method of claim 1,wherein probe output signal characteristics comprise one or more of aplethysmograph signal amplitude and signal attenuation.
 5. The method ofclaim 1 wherein the LED has a plurality of transmission pulses.
 6. Themethod of claim 1, wherein the method is carried out during continuouspatient monitoring.
 7. A method for an optical probe including a lightemitting diode (LED) driven by a drive circuit including an LED drivevoltage regulator and an LED current regulator, the method comprising:setting initial values of the drive circuit including at least one LEDdrive circuit operating parameter and an LED drive voltage; with the LEDdrive voltage and the at least one LED drive circuit operating parameterat the initial values, measuring probe output signal characteristics;adjusting the at least one LED drive circuit operating parameter basedon the probe output signal characteristics; estimating LED drive circuitvoltage losses based on the at least one LED drive circuit operatingparameter; and adjusting the LED drive voltage according to the LEDdrive circuit voltage losses.
 8. The method of claim 7, wherein the atleast one LED drive circuit operating parameter is one or more of LEDcurrent, LED pulse length, LED pulse frequency, and current regulatorreference voltage.
 9. The method of claim 8, further comprising furtheradjusting the at least one LED drive circuit operating parameter inresponse to a change in one or more of the drive circuit operatingparameters.
 10. The method of claim 7, wherein probe output signalcharacteristics comprise one or more of a plethysmograph signalamplitude and a signal attenuation.
 11. A system comprising: an opticalprobe including: a drive circuit including an LED drive voltageregulator and an LED current regulator; a light emitting diode (LED)driven by the drive circuit; and a control unit having instructionsstored in memory and configured to: set initial values of the drivecircuit including of at least one LED drive circuit operating parameterand an LED drive voltage, with the LED drive voltage and the at leastone LED drive circuit operating parameter at the initial values, measureprobe output signal characteristics, adjust the at least one LED drivecircuit operating parameter based on the probe output signalcharacteristics, estimate LED drive circuit voltage losses based on theat least one LED drive circuit operating parameter, and adjust the LEDdrive voltage according to the LED drive circuit voltage losses.
 12. Thesystem of claim 11, wherein the at least one LED drive circuit operatingparameter is one or more of LED current, LED pulse length, LED pulsefrequency, and current regulator reference voltage.
 13. The system ofclaim 11, wherein the probe output signal characteristics comprise oneor more of a plethysmograph signal amplitude and a signal attenuation.14. The system of claim 13, further comprising further adjusting the atleast one LED drive circuit operating parameter in response to a changein one or more of the drive circuit operating parameters.
 15. The systemof claim 11 wherein the probe is a pulse oximeter probe.
 16. The systemof claim 15 wherein the system is a multi-wavelength pulse oximetrysystem.
 17. The system of claim 11 further comprising a display unit.18. The system of claim 17 wherein physiological parameters obtained viathe probe are displayed on the display unit.
 19. The system of claim 18wherein the control unit and memory are located remotely from theoptical probe.